Our medium-term bioassay method is based on the theory of two-stage cancer development (initiation and promotion), which has been demonstrated experimentally in many organs and is now viewed as generally applicable in elucidating the mechanisms underlying onset of human cancer. Using this method, we at the DIMS Institute of Medical Science can detect the carcinogenic action of a chemical substance in a relatively short time and with a high degree of reliability. Our current medium—term bioassays for individual organs, development in collaboration with Nagoya City University, include examples for the liver, which can be concluded within 8 weeks, esophagus, stomach, nasal cavity, lungs, mammary glands, thyroid, kidney, bladder, and skin, as well as for leukemia.

We also have a multi-organ carcinogenesis bioassay tha can detect carcinogenicity and promotion effects in various organs in the same animal simultaneously, rather than concentrating only on a single organ.

This medium-term carcinogenesis bioassay systems is fully backed by data and boasts a solid record of successful results.